α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation
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چکیده
منابع مشابه
α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation
Background Blocking of DNA synthesis through inhibition of ribonucleotide reductase has been proposed to be the main mechanism of anti-neoplastic action for a-N-heterocyclic thiosemicarbazones. Currently the best-studied agent of this class of compounds is triapine (3-amino-2-carboxaldehyde thiosemicarbazone), which has been tested in several phase I and II clinical trials. We synthesized triap...
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Clinical failure of novel drugs is often related to their rapid metabolism and excretion. This highlights the importance of elucidation of their pharmacokinetic profile already at the preclinical stage of drug development. Triapine, the most prominent representative of α-N-heterocyclic thiosemicarbazones, was investigated in more than 30 clinical phase I/II trials, but the results against solid...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2010
ISSN: 1471-2210
DOI: 10.1186/1471-2210-10-s1-a20